SYCP3 drives prostate cancer metastasis — now out in Scientific Reports
The hit that came out of our genome-wide CRISPR/Cas9 screen is now published. SYCP3, a meiosis-specific gene not normally expressed in somatic tissue, is frequently upregulated in prostate tumours from…
C3G downregulation enhances stemness in glioblastoma through PKM2
New collaborative work on the C3G signalling axis: its downregulation enhances stem-like properties in glioblastoma cells by promoting the upregulation of the glycolytic enzyme PKM2. Cueto-Remacha M, Manzano S, Iniesta-González…
Neuroinflammation as a driver of Down syndrome-associated Alzheimer’s disease
Our continuing collaboration with the group of Hakon Hakonarson at the Children’s Hospital of Philadelphia examines the role of neuroinflammation as a driver of Alzheimer’s disease in people with Down…
How CRISPR screens are dissecting stress adaptation in cancer
A review on how CRISPR-based genetic screens are being used to take apart the pathways that cancer cells use to survive stress — and what that tells us about where…
SLU7 as a new cancer target
Collaborative work demonstrating SLU7, a splicing regulator, as a new target in cancer. Rojo C, Otero A, Elizalde M, et al. Demonstration of SLU7 as a new cancer target. Biomedicine…
Deleting C3G in hepatocytes impairs liver maturation and alters glucose homeostasis
Hepatocyte-specific deletion of C3G impairs full liver maturation and alters glucose homeostasis — another piece of the C3G story we have been building with the groups of Almudena Porras and…
Neuropilin-2 and the escape from dormancy of disseminated tumour cells
The published version of our work on dormancy: stromal TGFβ1 upregulates neuropilin-2 in disseminated tumour cells in the lung, driving their escape from dormancy and the outgrowth of metastasis. Understanding…
PRMT7 Inhibitors for the Treatment of Prostate Cancer
We are delighted to see that, building on work performed at the ONCOCRISPR Lab, a new inhibitor with promising antitumour properties has been developed against PRMT7 — the gene our…
Our RESEARCH in JAMA Neurology
Thanks to our work, a new therapy using an old ally has been tested for an angiopathy that until now was considered incurable. A genuine game-changer for these patients. Snorradottir…
CRISPR/Cas9 technology wins Nobel prize
Genetic scissors: a tool for rewriting the code of life Emmanuelle Charpentier and Jennifer A. Doudna have discovered one of gene technology’s sharpest tools: the CRISPR/Cas9 genetic scissors. Using these,…
Diario de Burgos
Identifican una proteína que frena la metástasis en cáncer de próstata
BLOG LENOVO
Álvaro Gutiérrez-Uzquiza: “Debe haber un compromiso entre industria farmacéutica e instituciones públicas para investigar las enfermedades raras”https://www.bloglenovo.es/alvaro-gutierrez-uzquiza/
