Publications

ORCID: 0000-0002-0446-4131
Google Scholar: Gutierrez-Uzquiza
Web of Science ResearcherID: E-4073-2012

44 publications indexed in PubMed · h-index 18 · 1,286 citations · 88% in Q1 journals. Metrics as of January 2026 — see the ORCID, Google Scholar and Web of Science profiles above for live figures.

2026

  1. Rodrigo-Faus M, del Monte-Garcia I, Hermosilla-Trespaderne M, Gordo-Vega A, Vidal N, Puente J, Saiz-Pardo M, Cuesta ÁM, Qu HQ, Hakonarson H, Porras A, Sanchez-Parcerisa D, Bragado P, Gutierrez-Uzquiza A. SYCP3 enhances prostate cancer metastasis and modulates the DNA damage response pathway. Sci Rep. 2026 Aug 3. doi: 10.1038/s41598-026-64241-0.
  2. Cueto-Remacha M, Manzano S, Iniesta-González M, Mancebo J, Martin-Serna P, Palao N, Baquero C, López-Pastor AR, Peralbo-Avilés C, Gutierrez-Uzquiza A, Cuesta ÁM, Bragado P, Guerrero C, Porras A. C3G downregulation enhances stemness in glioblastoma cells by promoting PKM2 upregulation. Int J Biol Sci. 2026;22(12):6500-6520. doi: 10.7150/ijbs.126349.
  3. Qu HQ, Snorradottir AO, Gutierrez-Uzquiza A, Kao C, March M, Hakonarson H. Neuroinflammation as a driver of Down syndrome-associated Alzheimer’s disease. Brain Behav Immun. 2026 Jul;135:106513. doi: 10.1016/j.bbi.2026.106513.
  4. Mokhles F, Moosavi MA, Gutierrez-Uzquiza A, Velasco G, Li M, Cordani M. Unraveling stress-adaptation pathways in cancer: functional dissection through CRISPR-based genetic screens. Cancer Lett. 2026;644:218246. doi: 10.1016/j.canlet.2026.218246.

2025

  1. Rojo C, Otero A, Elizalde M, Azkona M, Barbero R, Latasa MU, Uriarte I, Gutierrez-Uzquiza A, Alignani D, Guembe L, Lujambio A, Pastor F, Fernández-Barrena MG, Ávila MA, Arechederra M, Berasain C. Demonstration of SLU7 as a new cancer target. Biomed Pharmacother. 2025 Dec;193:118854. doi: 10.1016/j.biopha.2025.118854.
  2. Palao N, Mancebo J, Baquero C, Iniesta-González M, Cueto-Remacha M, Rodrigo-Faus M, Gutierrez-Uzquiza A, Bragado P, Cuesta ÁM, Sánchez A, Guerrero C, Porras A. Deletion of C3G in hepatocytes impairs full liver maturation and alters glucose homeostasis. Cell Death Dis. 2025 Oct 7;16(1):711. doi: 10.1038/s41419-025-08031-y.
  3. Recalde-Percaz L, de la Guia-Lopez I, Linzoain-Agos P, Noguera-Castells A, Rodrigo-Faus M, (…), Porras A, Gutierrez-Uzquiza A, Carbó N, Bragado P. Neuropilin-2 upregulation by stromal TGFβ1 induces lung disseminated tumor cells dormancy escape and promotes metastasis outgrowth. Neoplasia. 2025 Oct;68:101220. doi: 10.1016/j.neo.2025.101220.
  4. Sánchez-Ortega M, Garrido A, Sanz L, Torres-Pérez R, Hernandez C, Gutierrez-Uzquiza A, Tsao MS, Carrera AC. Double vulnerability of active-NRF2 lung squamous cell carcinoma to NRF2 and TRIM24. Mol Cancer. 2025 Jul 17;24(1):197. doi: 10.1186/s12943-025-02401-y.
  5. Snorradottir AO, Gutierrez-Uzquiza A, Bragado P, March ME, Kao C, Arkink EB, Jonsdottir S, Sigurdardottir A, Isaksson HJ, Mariasdóttir HL, Bjorgvinsdottir OY, Kowal NM, Heimisdottir HL, Sverrisdottir A, Palsdottir A, Bjornsson HT, Hakonarson H. N-Acetylcysteine for hereditary cystatin C amyloid angiopathy: a nonrandomized clinical trial. JAMA Neurol. 2025 May 1;82(5):486-494. doi: 10.1001/jamaneurol.2025.0326.
  6. Baquero C, Iniesta-González M, Palao N, Fernández-Infante C, Cueto-Remacha M, Mancebo J, de la Cámara-Fuentes S, Rodrigo-Faus M, Valdecantos MP, Valverde AM, Sequera C, Manzano S, Cuesta ÁM, Gutierrez-Uzquiza A, Bragado P, Guerrero C, Porras A. Platelet C3G protects from liver fibrosis, while enhancing tumor growth through regulation of the immune response. J Pathol. 2025 Apr;265(4):502-517. doi: 10.1002/path.6403.
  7. Gutierrez-Uzquiza A, Bragado P. Targeted human editing using CRISPR technology in neural stem cells. Methods Mol Biol. 2025;2899:233-243. doi: 10.1007/978-1-0716-4386-0_16.

2024

  1. Fernández-Nogueira P, Linzoain-Agos P, Cueto-Remacha M, De la Guia-Lopez I, Recalde-Percaz L, Parcerisas A, Gascon P, Carbó N, Gutierrez-Uzquiza A, Fuster G, Bragado P. Role of semaphorins, neuropilins and plexins in cancer progression. Cancer Lett. 2024 Dec 1;606:217308. doi: 10.1016/j.canlet.2024.217308. Epub 2024 Oct 28.
  2. Ahmad R, Barcellini A, Baumann K, Benje M, Bender T, Bragado P, Charalampopoulou A, Chowdhury R, Davis AJ, Ebner DK, Eley J, Kloeber JA, Mutter RW, Friedrich T, Gutierrez-Uzquiza A, Helm A, Ibáñez-Moragues M, Iturri L, Jansen J, Morcillo MÁ, Puerta D, Kokko AP, Sánchez-Parcerisa D, Scifoni E, Shimokawa T, Sokol O, Story MD, Thariat J, Tinganelli W, Tommasino F, Vandevoorde C, von Neubeck C. Particle Beam Radiobiology Status and Challenges: A PTCOG Radiobiology Subcommittee Report. Int J Part Ther. 2024 Aug 8;13:100626. doi: 10.1016/j.ijpt.2024.100626. eCollection 2024 Sep.
  3. García-Sáez J, Figueroa-Fuentes M, González-Corralejo C, Roncero C, Lazcanoiturburu N, Gutiérrez-Uzquiza Á, Vaquero J, González-Sánchez E, Bhutia K, Calero-Pérez S, Maina F, Traba J, Valverde ÁM, Fabregat I, Herrera B, Sánchez A. Uncovering a Novel Functional Interaction Between Adult Hepatic Progenitor Cells, Inflammation and EGFR Signaling During Bile Acids-Induced Injury.Int J Biol Sci. 2024 Apr 8;20(7):2339-2355. doi: 10.7150/ijbs.90645. eCollection 2024.
  4. Maria Rodrigo-Faus, Africa Vincelle-Nieto, Natalia Vidal, Javier Puente, Melchor Saiz-Pardo, Alejandra Lopez-Garcia, Marina Mendiburu-Eliçabe, Nerea Palao, Cristina Baquero, Angel M Cuesta, Hui-Qi Qu, Hakon Hakonarson, Monica Musteanu, Armando Reyes-Palomares, Almudena Porras, Paloma Bragado, Alvaro Gutierrez-Uzquiza. CRISPR/Cas9 screenings unearth protein arginine methyltransferase 7 as a novel driver of metastasis in prostate cancer. Cancer Letter . 2024 Apr 28:588:216776. doi: 10.1016/j.canlet.2024.216776. Epub 2024 Mar 2.

2023

  1. Martin-Morales L, Manzano S, Rodrigo-Faus M, Vicente-Barrueco A, Lorca V, Núñez-Moreno G, Bragado P, Porras A, Caldes T, Garre P, Gutierrez-Uzquiza A .Germline gain-of-function MMP11 variant results in an aggressive form of colorectal cancer. Int J Cancer. 2023 Jan 15;152(2):283-297. doi: 10.1002/ijc.34289. Epub 2022 Oct 3.

2022

  1. Palao N, Sequera C, Cuesta ÁM, Baquero C, Bragado P, Gutierrez-Uzquiza A, Sánchez A, Guerrero C, Porras A. C3G down-regulation enhances pro-migratory and stemness properties of oval cells by promoting an epithelial-mesenchymal-like process. Int J Biol Sci. 2022 Sep 25;18(15):5873-5884. doi: 10.7150/ijbs.73192. eCollection 2022.
  2. España S, Sánchez-Parcerisa D, Bragado P, Gutiérrez-Uzquiza Á, Porras A, Gutiérrez-Neira C, Espinosa A, Onecha VV, Ibáñez P, Sánchez-Tembleque V, Udías JM, Fraile LM. In vivo production of fluorine-18 in a chicken egg tumor model of breast cancer for proton therapy range verification. Sci Rep. 2022 Apr 30;12(1):7075. doi: 10.1038/s41598-022-11037-7.

2021

  1. Manzano S, Gutierrez-Uzquiza A, Bragado P, Cuesta AM, Guerrero C, Porras A. C3G Protein, a New Player in Glioblastoma.Int J Mol Sci. 2021 Sep 16;22(18):10018. doi: 10.3390/ijms221810018.
  2. Fernández-Nogueira P, Fuster G, Gutierrez-Uzquiza Á, Gascón P, Carbó N, Bragado P. Cancer-Associated Fibroblasts in Breast Cancer Treatment Response and Metastasis. Cancers (Basel). 2021 Jun 23;13(13):3146. doi: 10.3390/cancers13133146.
  3. Garcia-Garcia S, Rodrigo-Faus M, Fonseca N, Manzano S, Győrffy B, Ocaña A, Bragado P, Porras A, Gutierrez-Uzquiza A. HGK promotes metastatic dissemination in prostate cancer. Sci Rep. 2021 Jun 10;11(1):12287. doi: 10.1038/s41598-021-91292-2.
  4. Pancione M, Cerulo L, Remo A, Giordano G, Gutierrez-Uzquiza Á, Bragado P, Porras A. Centrosome Dynamics and Its Role in Inflammatory Response and Metastatic Process. Biomolecules. 2021 Apr 23;11(5):629. doi: 10.3390/biom11050629.
  5. Samuel España, Daniel Sánchez-Parcerisa, Paula Ibáñez, Víctor Sánchez-Tembleque, Jose Manuel Udías, Víctor V. Onecha, Alvaro Gutierrez-Uzquiza, et al. Direct proton range verification using oxygen-18 enriched water as a contrast agent. Radiation Physics and Chemistry. Volume 182, May 2021, 109385
  6. Michael E. March*, Alvaro Gutierrez-Uzquiza*, Asbjorg Osk Snorradottir, Leticia S. Matsuoka, et all. NAC blocks Cystatin-C Aggregation and Possible Disease Progression in HCCAA patients. Nature Communication (2021).  March 23. doi: 10.1038/s41467-021-22120-4.
  7. Sara Manzano, Alvaro Gutierrez-Uzquiza*, Paloma Bragado, Celia Sequera, Óscar Herranz, María Rodrigo-Faus, Patricia Jauregui, Stephanie Morgner, I Rubio, Carmen Guerrero, and Almudena Porras. C3G down-regulation induces the acquisition of a mesenchymal phenotype that enhances aggressiveness of glioblastoma cells. Cell Death & Disease. (2021). Apr. * Senior author.
  8. Mazal A, Vera Sanchez JA, Sanchez-Parcerisa D, Udias JM, España S, Sanchez-Tembleque V, Fraile LM, Bragado P, Gutierrez-Uzquiza A, Gordillo N, Garcia G, Castro Novais J, Perez Moreno JM, Mayorga Ortiz L, Ilundain Idoate A, Cremades Sendino M, Ares C, Miralbell R, Schreuder Biological and Mechanical Synergies to Deal With Proton Therapy Pitfalls: Minibeams, FLASH, Arcs, and Gantryless Rooms. N.Front Oncol. (2021). Jan 21;10:613669. doi: 10.3389/fonc.2020.613669. eCollection 2020.

2020

  1. Sequera C, Bragado P, Manzano S, Arechederra M, Richelme S, Gutiérrez-Uzquiza A, Sánchez A, Maina F, Guerrero C, Porras A. C3G Is Upregulated in Hepatocarcinoma, Contributing to Tumor Growth and Progression and to HGF/MET Pathway Activation. Cancers (2020) Aug 14;12(8):2282. doi: 10.3390/cancers12082282.PMID: 32823931 
2019
  1. Dong Li, Michael E. March, Alvaro Gutierrez-Uzquiza , Charlly Kao, Christoph Seiler, et al. “ARAF recurrent mutation causes central conducting lymphatic anomaly treatable with a MEK inhibitor”. Nature Medicine. 2019 Jul;25(7):1116-1122
  2. Zhou N, Gutierrez-Uzquiza A, Zheng XY, Chang R, Vogl DT, Garfall AL, Bernabei L, Saraf A, Florens L, Washburn MP, Illendula A, Bushweller JH, Busino L. “RUNX proteins desensitize multiple myeloma to lenalidomide via protecting IKZFs from degradation”. Leukemia. (2019) Feb 13
2018
  1. Li D, Wenger TL, Seiler C, March M, Gutierrez-Uzquiza A, et al. “Pathogenic variant in EPHB4 results in central conducting lymphatic anomaly ”. Human Molecular Genetics. (2018), Sep 15.
2016
  1. N Priego, M Arechederra, C Sequera, P Bragado, A Vázquez-Carballo, A. Gutierrez-Uzquiza, V Martín-Granado, JJ Ventura, MG Kazanietz, C Guerrero, A Porras. “C3G knock-down enhances migration and invasion by increasing Rap1-mediated p38α activation, while it impairs tumor growth through p38α-independent mechanisms.” Oncotarget (2016) Jun;7.
2015 and before
  1. Gutierrez-Uzquiza A, Lopez-Haber C, Jernigan DL, Fatatis A, Kazanietz M. “PKCε Is an Essential Mediator of Prostate Cancer Bone Metastasis“. Mol Cancer Res. (2015) Sep;13(9):1336-46. (Article selected to be featured in section “Molecular Cancer Research HIGHLIGHTS”).
  2. Arechederra M, Priego N, Vázquez-Carballo A, Sequera C, Gutiérrez-Uzquiza Á, Cerezo-Guisado MI, Ortiz-Rivero S, Roncero C, Cuenda A, Guerrero C, Porras A. “p38 MAPK Down-regulates Fibulin 3 Expression through Methylation of Gene Regulatory Sequences: ROLE IN MIGRATION AND INVASION”. J Biol Chem. (2015).
  3. Wang H, Gutierrez-Uzquiza A, Garg R, Barrio-Real L, Abera MB, Lopez-Haber C, Rosemblit C, Lu H, Abba M, Kazanietz MG. (2014). “Transcriptional regulation of oncogenic protein kinase Cε (PKCε) by STAT1 and Sp1 proteins”. J Biol Chem. Jul (2014).
  4. A. Gutierrez-Uzquiza, L. Zubeldia-Brenner, L. Barrio-Real, H.Wang, M.G. Kazanietz, F. Coluccio Leskow. (2014). “β3-Chimaerin, a novel member of the chimaerin Rac-GAP family”. Molecular Biology reports (2014)
  5. Arechederra M., Carmona R., González-Nuñez M., Gutiérrez-Uzquiza A., Bragado P., Cruz-González I., Cano E., Guerrero C.; Sánchez A., López-Novoa J.M., Schneider M.D., Maina F., Muñoz-Chápuli, R., and Porras A. (2013). “Met signaling in cardiomyocytes is required for normal cardiac function in adult mice”. Molecular Basis of Disease. (2013). Aug 28.
  6. Gutierrez-Uzquiza A., Colon-Gonzalez F., Leonard T. A., Canagarajah B. J., Wang HB, Bruce J. Mayer B.J., Hurley J.H. and Kazanietz M.G. (2013). “Coordinated activation of the rac-gap β2-chimaerin by an atypical proline-rich domain and diacylglycerol”. Nature Communication. (2013) 4:1849.
  7. Wertheimer E., Gutierrez-Uzquiza A., Rosemblit C., Lopez-Haber C., Sosa M.S., Kazanietz M.G. (2012). “Rac signaling in breast cancer: a tale of GEFs and GAPs.” Cell Signaling (2012) Feb;24(2):353-62.
  8. Gutierrez-Uzquiza A, Arechederra M., Bragado P., Aguirre-Ghiso J.A., Porras A. “p38α mediates cell survival in response to oxidative stress via induction of antioxidant genes: effect on the p70S6K pathway”. J Biol Chem (2012)-Jan 20;287(4):2632-42.
  9. Gutierrez-Uzquiza, A., Arechederra, M., Molina, I., Baños, R., Maia, V., Benito, M. , Guerrero, C., and Porras, A. (2010). “C3G down-regulates p38 MAPK activity in response to stress by Rap-1 independent mechanisms: Involvement in cell death”. Cell Signaling (2010) 22(3): 533-42.
  10. Maia, V., Sanz, M., Gutierrez-Berzal, J., de Luis, A., Gutierrez-Uzquiza, A., Porras, A., and Guerrero, C. (2009) “C3G silencing enhances STI-571-induced apoptosis in CML cells through p38 MAPK activation, but it antagonizes STI-571 inhibitory effect on survival” Cell Signaling (2009). 21, 1229-123.
  11. Zuluaga, S., Gutierrez-Uzquiza, A., Bragado, P., Álvarez-Barrientos, A., Benito, M., Nebreda, A., and Porras, P. (2007). “p38alpha MAPK can positively or negatively regulate Rac-1 activity depending on the presence of serum” FEBS Lett. (2007) 581(20): 3819-25.
  12. Zuluaga, S., Alvarez-Barrientos, A., Gutierrez-Uzquiza, A., Benito, M., Nebreda, A. and Porras A. (2007). “Negative regulation of Akt activity by p38αMAP Kinase in cardiomyocytes involves membrane localization of PP2A through interaction with Caveolin-1.” Cell Signaling (2007) 19 (1): 62-74.